The medial entorhinal spatial map is built on the theta inhibitory scaffold Psychology and Neuroscience Friday Seminar: Dr Julija Krupic (UCL)

The principal neurons of the medial entorhinal cortex (mEC) serve as fundamental components of the parahippocampal cognitive map, playing a key role in spatial memory and navigation. Yet, the network mechanisms that enable this map's formation remain poorly understood. To explore how different functional cell types cooperate to generate stable spatial representations, Dr Julija Krupic and her team recorded activity from hundreds of mEC neurons in mice navigating virtual environments with varying numbers of visual landmarks, ranging from none to several cues.

In this talk, Dr Krupic will discuss how specialised mEC cells collectively encode visual landmarks and construct a spatial map coordinated by inhibitory interneurons.